Anti-Mouse CD304/NRP1 Antibody (YW64.3) (MT070013)

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Datasheet

Overview

Catalog No.

MT070013

Description

Anti-Mouse CD304/NRP1 Antibody (YW64.3) [YW64.3] (MT070013) is a mouse monoclonal antibody detecting CD304 in ELISA, FCM. Suitable for Human and Mouse.

Highlights

●Flow Cytometry — Validated for flow cytometry applications.

Species reactivity

Human, Mouse

Applications

ELISA, FCM

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

YW64.3

Clonality

Monoclonal

Target

Neuropilin-1, Vascular endothelial cell growth factor 165 receptor, CD304, NRP1, NRP, VEGF165R

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O14786, P97333

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Neuropilin-1 (CD304/NRP1) is a ~103 kDa protein. Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis.

1. Gagnon, ML. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 2573-8. PMID: 10688880

2. He, Z. et al. (1997) Cell 90, 739-51. PMID: 9288753

3. Soker, S. et al. (1998) Cell 92, 735-45. PMID: 9529250

4. Teesalu, T. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 16157-62. PMID: 19805273

5. Issitt, T. et al. (2019) iScience 11, 205-223. PMID: 30623799

Note

For research use only

Images

SDS-PAGE

SDS-PAGE for Anti-Mouse CD304/NRP1 Antibody (YW64.3)

References

Datasheet

Anti-Mouse CD304/NRP1 Antibody (YW64.3).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse CD304/NRP1 Antibody (YW64.3) (MT070013)

Overview

Images

References

Datasheet

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