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Anti-Mouse CD350/FZD10 Polyclonal Antibody (MV512014)

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Overview
Catalog No.MV512014
Description
Anti-Mouse CD350/FZD10 Polyclonal Antibody (MV512014) is a rabbit polyclonal antibody detecting CD350. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse CD350/FZD10 (Asn61-Asp143).
Target CD350, Frizzled-10, Fz-10, Fz10, Fzd10
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q8BKG4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Frizzled-10 (CD350/FZD10) is a ~65 kDa protein. Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins.

1. Wang, Z. et al. (2005) Molecular and cellular biology 25, 5022-30. PMID: 15923619
Note For research use only
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Datasheet
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Formula
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Anti-Mouse CD350/FZD10 Polyclonal Antibody

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