Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody (MV829014)

Name: Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody
Brand: abinScience
SKU: MV829014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

MV829014

Description

Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody (MV829014) is a rabbit polyclonal antibody detecting Dectin-1/CLEC7A in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Mouse CD369/CLEC7A (Asn122-Leu244).

Target

C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Accession

Q6QLQ4

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

C-type lectin domain family 7 member A (CD369/CLEC7A) is a ~27 kDa protein. Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia.

1. Brown, GD. et al. (2001) Nature 413, 36-7. PMID: 11544516

2. Adachi, Y. et al. (2004) Infection and immunity 72, 4159-71. PMID: 15213161

3. Taylor, PR. et al. (2007) Nature immunology 8, 31-8. PMID: 17159984

4. Gantner, BN. et al. (2003) The Journal of experimental medicine 197, 1107-17. PMID: 12719479

5. Viriyakosol, S. et al. (2005) Infection and immunity 73, 1553-60. PMID: 15731053

6. Yadav, M. et al. (2006) Blood 108, 3168-75. PMID: 16825490

7. Campuzano, A. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 3296-3306. PMID: 32358020

8. Rogers, NC. et al. (2005) Immunity 22, 507-17. PMID: 15845454

Note

For research use only.

Images

References

Datasheet

Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse Dectin-1/CLEC7A Polyclonal Antibody (MV829014)

Overview

Images

References

Datasheet

SDS

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