Anti-Mouse CD37 Recombinant Antibody (252-3#), PE (MY564127)

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Catalog No.	MY564127
Description	Anti-Mouse CD37 Antibody (252-3#), PE [252-3#] (MY564127) is a mouse monoclonal antibody detecting CD37 in ELISA, FCM. Suitable for Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	252-3#
Conjugation	PE
Clonality	Monoclonal
Target	Leukocyte antigen CD37, CD37
Endotoxin level	Please contact with the lab for this information.
Accession	Q61470
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Leukocyte antigen CD37 (TSPAN26) is a ~31 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. 1. Knobeloch, KP. et al. (2000) Molecular and cellular biology 20, 5363-9. PMID: 10891477 2. van Spriel, AB. et al. (2012) Science signaling 5, ra82. PMID: 23150881 3. Gartlan, KH. et al. (2013) European journal of immunology 43, 1208-19. PMID: 23420539 4. Wee, JL. et al. (2015) Journal of immunology (Baltimore, Md. : 1950) 195, 5770-9. PMID: 26566675
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Mouse CD37 Recombinant Antibody (252-3#), PE.pdf

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Anti-Mouse CD37 Recombinant Antibody (252-3#), PE (MY564127)

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