Anti-Mouse CLEC6A Polyclonal Antibody (MA366014)

Name: Anti-Mouse CLEC6A Polyclonal Antibody
Brand: abinScience
SKU: MA366014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

MA366014

Description

Anti-Mouse CLEC6A Polyclonal Antibody (MA366014) is a rabbit polyclonal antibody detecting CLEC6A in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse CLEC6A (Ile44-Leu209).

Target

DC-associated C-type lectin 2, DECTIN2, Dendritic cell-associated C-type lectin 2, CLECSF10, CLEC6A, C-type lectin domain family 6 member A, C-type lectin superfamily member 10, Dectin-2

Purification

Purified by antigen affinity column.

Accession

Q9JKF4

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

C-type lectin domain family 6 member A (CLEC6A) is a ~24 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas. Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses.

1. Sato, K. et al. (2006) The Journal of biological chemistry 281, 38854-66. PMID: 17050534

2. Robinson, MJ. et al. (2009) The Journal of experimental medicine 206, 2037-51. PMID: 19703985

3. Saijo, S. et al. (2010) Immunity 32, 681-91. PMID: 20493731

4. Campuzano, A. et al. (2020) Journal of immunology (Baltimore, Md. : 1950) 204, 3296-3306. PMID: 32358020

5. Barrett, NA. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 1119-28. PMID: 19124755

6. Ritter, M. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 20459-64. PMID: 21059925

Note

For research use only.

Images

References

Datasheet

Anti-Mouse CLEC6A Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse CLEC6A Polyclonal Antibody (MA366014)

Overview

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References

Datasheet

SDS

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