Anti-Mouse DSG2 Polyclonal Antibody (MC461014)

Name: Anti-Mouse DSG2 Polyclonal Antibody
Brand: abinScience
SKU: MC461014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

MC461014

Description

Anti-Mouse DSG2 Polyclonal Antibody (MC461014) is a rabbit polyclonal antibody detecting DSG2 in ELISA, IHC, WB. Suitable for Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse DSG2 (Val61-Asn386).

Target

CDHF5, HDGC, Desmoglein-2, DSG2, Cadherin family member 5

Purification

Purified by antigen affinity column.

Accession

O55111

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Desmoglein-2 (DSG2) is a ~122 kDa protein. A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Required for proliferation and viability of embryonic stem cells in the blastocyst, thereby crucial for progression of post-implantation embryonic development. Maintains pluripotency by regulating epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via interacting with and sequestering CTNNB1 to sites of cell-cell contact, thereby reducing translocation of CTNNB1 to the nucleus and subsequent transcription of CTNNB1/TCF-target genes. Promotes pluripotency and the multi-lineage differentiation potential of hematopoietic stem cells.

1. Eshkind, L. et al. (2002) European journal of cell biology 81, 592-8. PMID: 12494996

2. Park, J. et al. (2018) Stem cell reports 11, 115-127. PMID: 29910125

3. Ebert, LM. et al. (2016) Angiogenesis 19, 463-86. PMID: 27338829

4. Kant, S. et al. (2015) Circulation. Cardiovascular genetics 8, 553-63. PMID: 26085008

5. Myo Min, KK. et al. (2022) Cell death & disease 13, 911. PMID: 36309486

6. Xu, T. et al. (2024) Kidney international 105, 1035-1048. PMID: 38395410

Note

For research use only.

Images

References

Datasheet

Anti-Mouse DSG2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse DSG2 Polyclonal Antibody (MC461014)

Overview

Images

References

Datasheet

SDS

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