

| Catalog No. | MP294014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Mouse EGFLAM (Asp40-Thr236). | ||||||||
| Target | Pikachurin (EGF-like, fibronectin type-III and laminin G-like domain-containing protein) (Nectican) | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q4VBE4 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Pikachurin (EGFLAM) is a ~110 kDa protein. Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness. 1. Sato, S. et al. (2008) Nature neuroscience 11, 923-31. PMID: 18641643 2. Manabe, R. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 12849-54. PMID: 18757743 3. Orlandi, C. et al. (2018) Cell reports 25, 130-145.e5. PMID: 30282023 | ||||||||
| Note | For research use only. |
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