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Anti-Mouse FCRN/FCGRT Polyclonal Antibody (MX061014)

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Overview
Catalog No.MX061014
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse FCGRT/FCRN (Arg25-Ser292).
Target IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
Purification Purified by antigen affinity column.
Accession Q61559
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

IgG receptor FcRn large subunit p51 (FCGRT) is a ~40 kDa protein. Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation.

1. Ahouse, JJ. et al. (1993) Journal of immunology (Baltimore, Md. : 1950) 151, 6076-88. PMID: 7504013
Note For research use only.
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Formula
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V₁ (Stock Vol.)
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Anti-Mouse FCRN/FCGRT Polyclonal Antibody

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