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Anti-Mouse FPR1 Polyclonal Antibody (MB008014)

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Overview
Catalog No.MB008014
Description
Anti-Mouse FPR1 Polyclonal Antibody (MB008014) is a rabbit polyclonal antibody detecting fMet-Leu-Phe receptor; fMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor; Fpr1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant mouse FPR1 (Asp2-Val35&Ser92-Phe108&Arg171-Arg216&Gln278-Ile296).
Target fMet-Leu-Phe receptor; fMLP receptor; N-formyl peptide receptor; FPR; N-formylpeptide chemoattractant receptor; Fpr1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P33766
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

N-formyl peptide receptor 1 (FPR1) is a ~40 kDa protein. Pattern recognition G-protein coupled receptor (PRR/GPCR) involved in innate recognition of N-formyl-methionyl peptides derived from invading microbes and host mitochondria as pathogen- and damage-associated molecular patterns (PAMPs and DAMPs). Functions as a sensor of PAMPs and DAMPs released upon microbial infection or tissue damage, triggering immune cell activation and chemotaxis to eliminate pathogens and restore tissue homeostasis. Peptide binding leads to conformational changes coupled to heterotrimeric G(i) protein signaling. Upon GDP to GTP conversion, G(i)-alpha subunit dissociates from G-beta and G-gamma subunits. Free G(i)-alpha subunit inhibits cyclic adenylate cyclase and cAMP synthesis whereas the G-beta and G-gamma dimer activates downstream phospholipase C-beta and phosphoinositide 3-kinase signaling cascades leading to Ca(2+) influx.

1. Southgate, EL. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 1429-37. PMID: 18606697
2. Bufe, B. et al. (2015) The Journal of biological chemistry 290, 7369-87. PMID: 25605714
3. Gao, JL. et al. (1993) The Journal of biological chemistry 268, 25395-401. PMID: 8244972
4. Gao, JL. et al. (1999) The Journal of experimental medicine 189, 657-62. PMID: 9989980
5. McDonald, B. et al. (2010) Science (New York, N.Y.) 330, 362-6. PMID: 20947763
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Mouse FPR1 Polyclonal Antibody

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