Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8) (MV466013)

Name: Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8)
Brand: abinScience
SKU: MV466013
Price: 191 USD
Availability: InStock

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Price(USD): $

Spec:

50ug
100ug
1mg

Number:

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

MV466013

Species reactivity

Mouse

Applications

ELISA, FACS, Functional assay, Research in vivo

Host species

Rat

Isotype

IgG1, kappa

Clone ID

G23-8

Clonality

Monoclonal

Target

IL-23 subunit alpha, IL-23-A, IL-23p19, Il23a, Interleukin-23 subunit alpha, Interleukin-23 subunit p19

Endotoxin level

<1 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9EQ14

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-23 subunit alpha (IL-23 p19) is a ~22 kDa protein. Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells.

1. Oppmann, B. et al. (2000) Immunity 13, 715-25. PMID: 11114383

2. Wiekowski, MT. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 166, 7563-70. PMID: 11390512

3. Yen, D. et al. (2006) The Journal of clinical investigation 116, 1310-6. PMID: 16670770

4. Li, X. et al. (2010) Immunology letters 127, 100-7. PMID: 19900478

5. Happel, KI. et al. (2005) The Journal of experimental medicine 202, 761-9. PMID: 16157683

6. Mangan, PR. et al. (2006) Nature 441, 231-4. PMID: 16648837

Note

For research use only

Images

References

Datasheet

Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse IL-23 p19 Recombinant Antibody (G23-8) (MV466013)

Overview

Images

References

Datasheet

SDS

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