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Anti-Mouse IL17F Polyclonal Antibody (MV544014)

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Overview
Catalog No.MV544014
Description
Anti-Mouse IL17F Polyclonal Antibody (MV544014) is a rabbit polyclonal antibody detecting IL17F in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse IL17F (Ala21-Ala161).
Target IL17F, Interleukin-17F, IL-17F, Cytokine ML-1
Purification Purified by antigen affinity column.
Accession Q7TNI7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Interleukin-17F (IL17F) is a ~17 kDa protein. Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation. As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites.

1. Liang, SC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7791-9. PMID: 18025225
2. Ishigame, H. et al. (2009) Immunity 30, 108-19. PMID: 19144317
3. Gladiator, A. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 190, 521-5. PMID: 23255360
4. Oda, N. et al. (2005) American journal of respiratory and critical care medicine 171, 12-8. PMID: 15477493
5. Kuestner, RE. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 5462-73. PMID: 17911633
Note For research use only.
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Formula
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Anti-Mouse IL17F Polyclonal Antibody

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