

| Catalog No. | MV678014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Mouse IL31 (Ala31-Cys163). | ||||||||
| Tested applications | WB | ||||||||
| Target | Interleukin-31 (IL-31) | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q6EAL8 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Interleukin-31 (IL31) is a ~18 kDa protein. Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell survival in vitro. Induces RETNLA and serum amyloid A protein expression in macrophages. 1. Dillon, SR. et al. (2004) Nature immunology 5, 752-60. PMID: 15184896 2. Broxmeyer, HE. et al. (2007) Experimental hematology 35, 78-86. PMID: 17379091 3. Edukulla, R. et al. (2015) The Journal of biological chemistry 290, 13510-20. PMID: 25847241 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-IL31 polyclonal antibody at 1µg/ml on various samples.
Lane 1: RAW264.7 cell lysate
Lane 2: Mouse lung lysate
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