Anti-Mouse METRNL Polyclonal Antibody (HP868024)

Name: Anti-Mouse METRNL Polyclonal Antibody
Brand: abinScience
SKU: HP868024
Price: 96 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP868024

Description

Anti-Mouse METRNL Polyclonal Antibody (HP868024) is a rabbit polyclonal antibody detecting METRNL in ELISA, IHC, WB. Suitable for Rattus norvegicus and Mus musculus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse METRNL (Ser53-Glu311).

Target

METRNL

Purification

Purified by antigen affinity column.

Accession

Q8VE43

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

Meteorin-like protein, Subfatin, Metrnl

Background

Meteorin-like protein (METRNL) is a ~34 kDa protein. Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat.

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Mouse METRNL polyclonal antibody at 1ug/mL on recombinant Mouse METRNL (Catalog No. RP868012).

References

Datasheet