

| Catalog No. | MC624014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Mouse PLA2R1/PLA2R Polyclonal Antibody (MC624014) is a rabbit polyclonal antibody detecting PLA2R1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Species reactivity | Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Mouse PLA2R1/PLA2R (Ser242-Gly507). | ||||||||
| Target | PLA2R, 180 kDa secretory phospholipase A2 receptor, Secretory phospholipase A2 receptor, PLA2-R, M-type receptor, C-type lectin domain family 13 member C, Soluble PLA2-R, PLA2R1, Soluble PLA2R, CLEC13C | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q62028 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Secretory phospholipase A2 receptor (PLA2R1/PLA2R) is a ~170 kDa protein. Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. | ||||||||
| Note | For research use only. |
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