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Anti-Mouse PPIA Polyclonal Antibody (MX128014)

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Anti-Mouse PPIA Polyclonal Antibody
Anti-Mouse PPIA Polyclonal Antibody
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Overview
Catalog No.MX128014
Description
Anti-Mouse PPIA Polyclonal Antibody (MX128014) is a rabbit polyclonal antibody detecting Ppia. Suitable for Rat, Mouse, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse PPIA (Met1-Leu164).
Target Cyclophilin A, Cyclosporin A-binding protein, EC:5.2.1.8, PPIase A, Peptidyl-prolyl cis-trans isomerase A, Peptidyl-prolyl cis-trans isomerase A, N-terminally processed, Ppia, Rotamase A, SP18
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P17742
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Peptidyl-prolyl cis-trans isomerase A (PPIA) is a ~17 kDa protein. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation. Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2.

1. Wang, L. et al. (2014) Thrombosis and haemostasis 111, 873-82. PMID: 24429998
2. Lauranzano, E. et al. (2015) Brain : a journal of neurology 138, 974-91. PMID: 25678563
Note For research use only
Images
  • Anti-Mouse PPIA Polyclonal Antibody

    Western blot

    Western blot analysis was performed using anti-PPIA polyclonal antibody at 1ug/mL on various samples.
    Lane 1: HepG2 cell lysate
    Lane 2: NIH3T3 cell lysate
    Lane 3: K562 cell lysate
    Lane 4: Raji cell lysate
    Lane 5: Jurkat cell lysate
    Lane 6: PC-12 cell lysate
    Lane 7: 293T cell lysate
    Lane 8: Mouse brain lysate
    Lane 9: Rat brain lysate

References
Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Mouse PPIA Polyclonal Antibody

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