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Anti-Mouse PTTG1 Polyclonal Antibody (MF630014)

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Overview
Catalog No.MF630014
Description
Anti-Mouse PTTG1 Polyclonal Antibody (MF630014) is a rabbit polyclonal antibody detecting PTTG1. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse PTTG1 (Ala2-Ile199).
Target EAP1, Esp1-associated protein, PTTG, PTTG1, Pituitary tumor-transforming gene 1 protein, Securin, TUTR1, Tumor-transforming protein 1, hPTTG
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9CQJ7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Securin (PTTG1) is a ~21 kDa protein. Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1.

Note For research use only
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Anti-Mouse PTTG1 Polyclonal Antibody

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