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Anti-Mouse Rnaset2b Polyclonal Antibody (MD482014)

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Overview
Catalog No.MD482014
Description
Anti-Mouse Rnaset2b Polyclonal Antibody (MD482014) is a rabbit polyclonal antibody detecting Rnaset2b. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse Rnaset2b (Lys40-His259).
Target EC:4.6.1.19, Ribonuclease 6-B, Ribonuclease T2-B, Rnaset2b
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession C0HKG6
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Ribonuclease T2-B (Rnaset2b) is a ~29 kDa protein. Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria.

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Anti-Mouse Rnaset2b Polyclonal Antibody

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