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Anti-Mouse ROBO3 Polyclonal Antibody (MA318014)

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Overview
Catalog No.MA318014
Description
Anti-Mouse ROBO3 Polyclonal Antibody (MA318014) is a rabbit polyclonal antibody detecting ROBO3 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse ROBO3 (Gly173-Val345).
Target Roundabout-like protein 3, ROBO3, Roundabout homolog 3
Purification Purified by antigen affinity column.
Accession Q9Z2I4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Roundabout homolog 3 (ROBO3) is a ~149 kDa protein. Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself.

1. Sabatier, C. et al. (2004) Cell 117, 157-69. PMID: 15084255
2. Chen, Z. et al. (2008) Neuron 58, 325-32. PMID: 18466743
3. Zelina, P. et al. (2014) Neuron 84, 1258-72. PMID: 25433640
4. Zhuang, M. et al. (2019) Nucleic acids research 47, 4765-4777. PMID: 30843071
5. Pak, JS. et al. (2020) Nature communications 11, 1489. PMID: 32198364
Note For research use only.
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Formula
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Anti-Mouse ROBO3 Polyclonal Antibody

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