

| Catalog No. | MA988014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Mouse SEMA4A Polyclonal Antibody (MA988014) is a rabbit polyclonal antibody detecting SEMA4A. Suitable for Mouse.
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| Species reactivity | Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Mouse SEMA4A (Arg41-Cys546). | ||||||||
| Target | SEMA4A, SEMAB, SEMB, Sema B, Semaphorin-4A, Semaphorin-B | ||||||||
| Endotoxin level | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q62178 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Background | Semaphorin-4A (SEMA4A) is a ~83 kDa protein. Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. 1. Toyofuku, T. et al. (2007) The EMBO journal 26, 1373-84. PMID: 17318185 2. Yukawa, K. et al. (2010) International journal of molecular medicine 25, 225-30. PMID: 20043131 3. McDermott, JE. et al. (2018) Molecular and cellular neurosciences 92, 50-66. PMID: 29981480 4. Kumanogoh, A. et al. (2005) Immunity 22, 305-16. PMID: 15780988 5. Kumanogoh, A. et al. (2002) Nature 419, 629-33. PMID: 12374982 | ||||||||
| Note | For research use only |
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