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Anti-Mouse SEMA4A Polyclonal Antibody (MA988014)

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Overview
Catalog No.MA988014
Description
Anti-Mouse SEMA4A Polyclonal Antibody (MA988014) is a rabbit polyclonal antibody detecting SEMA4A. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse SEMA4A (Arg41-Cys546).
Target SEMA4A, SEMAB, SEMB, Sema B, Semaphorin-4A, Semaphorin-B
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q62178
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Semaphorin-4A (SEMA4A) is a ~83 kDa protein. Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2.

1. Toyofuku, T. et al. (2007) The EMBO journal 26, 1373-84. PMID: 17318185
2. Yukawa, K. et al. (2010) International journal of molecular medicine 25, 225-30. PMID: 20043131
3. McDermott, JE. et al. (2018) Molecular and cellular neurosciences 92, 50-66. PMID: 29981480
4. Kumanogoh, A. et al. (2005) Immunity 22, 305-16. PMID: 15780988
5. Kumanogoh, A. et al. (2002) Nature 419, 629-33. PMID: 12374982
Note For research use only
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