

| Catalog No. | MY108014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Mouse TH Polyclonal Antibody (MY108014) is a rabbit polyclonal antibody detecting Mouse TH in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Mouse TH (Lys170-Arg454). | ||||||||
| Target | Tyrosine 3-monooxygenase, 1.14.16.2, Tyrosine 3-hydroxylase, TH, Th | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P24529 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Tyrosine 3-monooxygenase (TH) is a ~55 kDa protein. Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa. In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity. Positively regulates the regression of retinal hyaloid vessels during postnatal development. 1. Nguyen, MT. et al. (2019) Nature cell biology 21, 420-429. PMID: 30936473 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-TH polyclonal antibody at 1ug/mL on various samples.
Lane 1: PC-12 cell lysate
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