

| Catalog No. | MA149014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Mouse Timd2/G9D3 protein (Ser21-Glu129). | ||||||||
| Target | T cell immunoglobulin and mucin domain containing 2, Timd2, G9D3 protein | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q8R183 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
||||||||
| Product Usage Information |
| ||||||||
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2/G9D3 protein) is a ~33 kDa protein. Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin. Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes. Plays also an important role in the regulation of Th2 immunity. Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation. 1. Chen, TT. et al. (2005) The Journal of experimental medicine 202, 955-65. PMID: 16203866 2. Valença, A. et al. (2021) Experimental eye research 202, 108292. PMID: 33065090 3. Chakravarti, S. et al. (2005) The Journal of experimental medicine 202, 437-44. PMID: 16043519 4. Han, J. et al. (2011) PloS one 6, e23800. PMID: 21886823 5. Kumanogoh, A. et al. (2002) Nature 419, 629-33. PMID: 12374982 | ||||||||
| Note | For research use only. |
Contact us for custom quotes, bulk requests and any other issues.
Mail: [email protected]
+86-27-65523339
Building C, No. 666, Shen Dun Si Lu, Wuhan, 430206, China
中文
English
한국어
日本語
Español
Français
Русский