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Anti-Mouse Timd2/G9D3 protein Polyclonal Antibody (MA149014)

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Overview
Catalog No.MA149014
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse Timd2/G9D3 protein (Ser21-Glu129).
Target T cell immunoglobulin and mucin domain containing 2, Timd2, G9D3 protein
Purification Purified by antigen affinity column.
Accession Q8R183
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2/G9D3 protein) is a ~33 kDa protein. Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin. Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes. Plays also an important role in the regulation of Th2 immunity. Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation.

1. Chen, TT. et al. (2005) The Journal of experimental medicine 202, 955-65. PMID: 16203866
2. Valença, A. et al. (2021) Experimental eye research 202, 108292. PMID: 33065090
3. Chakravarti, S. et al. (2005) The Journal of experimental medicine 202, 437-44. PMID: 16043519
4. Han, J. et al. (2011) PloS one 6, e23800. PMID: 21886823
5. Kumanogoh, A. et al. (2002) Nature 419, 629-33. PMID: 12374982
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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