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Anti-Mouse TREX1 Polyclonal Antibody (MV590014)

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Overview
Catalog No.MV590014
Description
Anti-Mouse TREX1 Polyclonal Antibody (MV590014) is a rabbit polyclonal antibody detecting Trex1 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse TREX1 (Met11-Ala223).
Target Three-prime repair exonuclease 1, 3.1.11.2, 3'-5' exonuclease TREX1, Trex1
Purification Purified by antigen affinity column.
Accession Q91XB0
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Three-prime repair exonuclease 1 (TREX1) is a ~33 kDa protein. Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Plays a key role in degradation of DNA fragments at cytosolic micronuclei arising from genome instability: its association with the endoplasmic reticulum membrane directs TREX1 to ruptured micronuclei, leading to micronuclear DNA degradation. Micronuclear DNA degradation is required to limit CGAS activation and subsequent inflammation.

1. Mazur, DJ. et al. (1999) The Journal of biological chemistry 274, 19655-60. PMID: 10391904
2. Mazur, DJ. et al. (2001) The Journal of biological chemistry 276, 17022-9. PMID: 11279105
3. Morita, M. et al. (2004) Molecular and cellular biology 24, 6719-27. PMID: 15254239
4. de Silva, U. et al. (2007) The Journal of biological chemistry 282, 10537-43. PMID: 17293595
5. Brucet, M. et al. (2007) The Journal of biological chemistry 282, 14547-57. PMID: 17355961
6. Brucet, M. et al. (2008) Protein science : a publication of the Protein Society 17, 2059-69. PMID: 18780819
7. Stetson, DB. et al. (2008) Cell 134, 587-98. PMID: 18724932
8. Pereira-Lopes, S. et al. (2013) Journal of immunology (Baltimore, Md. : 1950) 191, 6128-35. PMID: 24218451
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Mouse TREX1 Polyclonal Antibody

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