Anti-Mouse VLDLR Polyclonal Antibody (MX210014)

Name: Anti-Mouse VLDLR Polyclonal Antibody
Brand: abinScience
SKU: MX210014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

MX210014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Mouse VLDLR (Glu440-Asn684).

Target

Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R)

Purification

Purified by antigen affinity column.

Accession

P98156

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Very low-density lipoprotein receptor (VLDLR) is a ~96 kDa protein. Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway LRP8 and VLDLR form homo or heterooligomers. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 on its cytoplasmic tail. This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons.

1. Tacken, PJ. et al. (2000) Journal of lipid research 41, 2055-62. PMID: 11108739

2. Nguyen, A. et al. (2014) The Journal of biological chemistry 289, 1688-703. PMID: 24293365

3. Fuchigami, T. et al. (2013) Genes to cells : devoted to molecular & cellular mechanisms 18, 410-24. PMID: 23506116

4. Hack, I. et al. (2007) Development (Cambridge, England) 134, 3883-91. PMID: 17913789

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-Mouse VLDLR polyclonal antibody at 1ug/mL on recombinant Mouse VLDLR (Catalog No. MX210012).

References

Datasheet

Anti-Mouse VLDLR Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Mouse VLDLR Polyclonal Antibody (MX210014)

Overview

Images

References

Datasheet

SDS

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