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Anti-MRAS Polyclonal Antibody (HB573014)

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Overview
Catalog No.HB573014
Description
Anti-MRAS Polyclonal Antibody (HB573014) is a rabbit polyclonal antibody detecting Ras-related protein M-Ras; 3.6.5.2; Ras-related protein R-Ras3; MRAS; RRAS3 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant human MRAS (Met1-Gln204).
Target Ras-related protein M-Ras; 3.6.5.2; Ras-related protein R-Ras3; MRAS; RRAS3
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O14807, O08989, P97538
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Ras-related protein M-Ras (MRAS) is a ~23 kDa protein. Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The formation of the SMP complex only occurs when MRAS is GTP-bound. MRAS has low intrinsic GTPase activity and may require additional factors for activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities.

1. Rodriguez-Viciana, P. et al. (2006) Molecular cell 22, 217-30. PMID: 16630891
2. Higgins, EM. et al. (2017) JCI insight 2, e91225. PMID: 28289718
3. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504
4. Hauseman, ZJ. et al. (2022) Nature 609, 416-423. PMID: 35830882
5. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509
6. Bonsor, DA. et al. (2022) Nature structural & molecular biology 29, 966-977. PMID: 36175670
7. Bernal Astrain, G. et al. (2025) Nature communications 16, 647. PMID: 39809765
Note For research use only
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Anti-MRAS Polyclonal Antibody

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