

| Catalog No. | MX889014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-MUC2 Polyclonal Antibody (MX889014) is a rabbit polyclonal antibody detecting Mucin-2; MUC-2; Colonic mucin; MCM; Secreted gel-forming mucin; Muc2 in ELISA, IHC, WB. Suitable for Mouse and Rat.
Highlights
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| Species reactivity | Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant mouse MUC2 (Asn31-His350). | ||||||||
| Target | Mucin-2; MUC-2; Colonic mucin; MCM; Secreted gel-forming mucin; Muc2 | ||||||||
| Endotoxin level | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q80Z19, Q62635 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Mucin-2 (MUC2) is a ~479 kDa protein. Coats the epithelia of the intestines and other mucus membrane-containing organs to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of the colon mucus, which is mainly formed by large polymeric networks of MUC2 secreted by goblet cells that cover the exposed surfaces of intestine. MUC2 networks form hydrogels that guard the underlying epithelium from pathogens and other hazardous matter entering from the outside world, while permitting nutrient absorption and gas exchange. Acts as a divalent copper chaperone that protects intestinal cells from copper toxicity and facilitates nutritional copper unptake into cells. Binds both Cu(2+) and its reduced form, Cu(1+), at two juxtaposed binding sites: Cu(2+), once reduced to Cu(1+) by vitamin C (ascorbate) or other dietary antioxidants, transits to the other binding site. 1. Johansson, ME. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15064-9. PMID: 18806221 2. Johansson, ME. et al. (2009) Journal of proteome research 8, 3549-57. PMID: 19432394 3. Bergstrom, K. et al. (2020) Science (New York, N.Y.) 370, 467-472. PMID: 33093110 | ||||||||
| Note | For research use only |
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