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Anti-NCSTN Polyclonal Antibody (HV481014)

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Overview
Catalog No.HV481014
Description
Anti-NCSTN Polyclonal Antibody (HV481014) is a rabbit polyclonal antibody detecting NCSTN in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human NCSTN (Gln420-Asp655).
Target KIAA0253, Nicastrin, NCSTN
Purification Purified by antigen affinity column.
Accession Q92542
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Nicastrin (NCSTN) is a ~78 kDa protein. Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels.

1. Yu, G. et al. (2000) Nature 407, 48-54. PMID: 10993067
2. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784
3. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039
4. Bai, XC. et al. (2015) Nature 525, 212-217. PMID: 26280335
5. Yang, G. et al. (2019) Nature 565, 192-197. PMID: 30598546
6. Zhou, R. et al. (2019) Science (New York, N.Y.) 363. PMID: 30630874
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-NCSTN Polyclonal Antibody

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