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Anti-NR1H2/LXRb Polyclonal Antibody (HX964014)

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Overview
Catalog No.HX964014
Description
Anti-NR1H2/LXRb Polyclonal Antibody (HX964014) is a rabbit polyclonal antibody detecting NR1H2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human NR1H2/LXRb (Lys72-Glu460).
Target UNR, Oxysterols receptor LXR-beta, LXRB, NR1H2, Nuclear receptor subfamily 1 group H member 2, Liver X receptor beta, NER, Ubiquitously-expressed nuclear receptor, Nuclear receptor NER
Purification Purified by antigen affinity column.
Accession P55055
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Oxysterols receptor LXR-beta (NR1H2/LXRb) is a ~50 kDa protein. Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis.

1. Sakurabashi, A. et al. (2015) The Journal of steroid biochemistry and molecular biology 149, 80-8. PMID: 25661920
2. Venteclef, N. et al. (2010) Genes & development 24, 381-95. PMID: 20159957
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-NR1H2/LXRb Polyclonal Antibody

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