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Anti-OAS1 Polyclonal Antibody (HF612014)

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Overview
Catalog No.HF612014
Description
Anti-OAS1 Polyclonal Antibody (HF612014) is a rabbit polyclonal antibody detecting OAS1 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human OAS1 (Ser74-Pro165).
Target E18/E16, (2-5')oligo(A) synthase 1, 2-5A synthase 1, 2'-5'-oligoadenylate synthase 1, OAS1, OIAS, p46/p42 OAS
Purification Purified by antigen affinity column.
Accession P00973
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

2'-5'-oligoadenylate synthase 1 (OAS1) is a ~46 kDa protein. Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis.

1. Wickenhagen, A. et al. (2021) Science (New York, N.Y.) 374, eabj3624. PMID: 34581622
2. Magg, T. et al. (2021) Science immunology 6. PMID: 34145065
3. Huai, W. et al. (2025) Immunity 58, 797-810.e6. PMID: 40010341
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-OAS1 Polyclonal Antibody

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