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Anti-OAZ1 Polyclonal Antibody (HX222014)

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Overview
Catalog No.HX222014
Description
Anti-OAZ1 Polyclonal Antibody (HX222014) is a rabbit polyclonal antibody detecting OAZ1 in ELISA, IHC, WB. Suitable for Bovine, Chicken, and Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human OAZ1 (Phe95-Glu219).
Target OAZ1, OAZ, AZ1, Ornithine decarboxylase antizyme 1, ODC-Az
Purification Purified by antigen affinity column.
Accession P54368
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Ornithine decarboxylase antizyme 1 (OAZ1) is a ~25 kDa protein. Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter.

1. Kanerva, K. et al. (2008) The Biochemical journal 409, 187-92. PMID: 17900240
2. Wu, HY. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 11229-34. PMID: 26305948
3. Wu, D. et al. (2015) Scientific reports 5, 14738. PMID: 26443277
4. Lin, Y. et al. (2002) BMC cell biology 3, 15. PMID: 12097147
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-OAZ1 Polyclonal Antibody

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