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Anti-ORF8/ns8 Polyclonal Antibody (VK460014)

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Overview
Catalog No.VK460014
Description
Anti-ORF8/ns8 Polyclonal Antibody (VK460014) is a rabbit polyclonal antibody detecting ORF8 protein in ELISA, IHC, WB.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivitySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant SARS-CoV-2 ORF8/ns8 (Phe16-Ile121).
Target ORF8 protein, ORF8, Non-structural protein 8, ns8
Purification Purified by antigen affinity column.
Accession P0DTC8
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

ORF8 protein (ns8) is a ~13 kDa protein. Plays a role in modulating the host immune response. May act as a secreted virokine by mimicking interleukin-17A (IL17A), and thereby binding to the IL17RA receptor, leading to activation of the IL17 pathway and increased secretion of pro-inflammatory factors. Contributes to the cytokine storm during SARS-CoV-2 infection when secreted by unconventional pathway. May act by down-regulating major histocompability complex class I (MHC-I) at cell surface. May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58.

1. Chan, JF. et al. (2020) Lancet (London, England) 395, 514-523. PMID: 31986261
2. Wu, X. et al. (2022) mBio 13, e0040222. PMID: 35343786
3. Lin, X. et al. (2023) PLoS pathogens 19, e1011128. PMID: 36689483
4. Lin, X. et al. (2021) iScience 24, 102293. PMID: 33723527
5. Zhang, Y. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34021074
6. Matsuoka, K. et al. (2022) The Journal of biological chemistry 298, 101724. PMID: 35157849
7. Geng, H. et al. (2021) Frontiers in immunology 12, 679482. PMID: 34177923
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-ORF8/ns8 Polyclonal Antibody

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