Anti-P2RX7 Polyclonal Antibody (MV713014)

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Overview

Catalog No.

MV713014

Description

Anti-P2RX7 Polyclonal Antibody (MV713014) is a rabbit polyclonal antibody detecting P2X purinoceptor 7; P2X7; ATP receptor; P2Z receptor; Purinergic receptor; P2rx7; P2x7 in ELISA, IHC, WB. Suitable for Rat and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Rat, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant mouse P2RX7 (Gln52-Asp329).

Target

P2X purinoceptor 7; P2X7; ATP receptor; P2Z receptor; Purinergic receptor; P2rx7; P2x7

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

Q9Z1M0, Q64663

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

P2X purinoceptor 7 (P2RX7) is a ~68 kDa protein. ATP-gated nonselective transmembrane cation channel. Requires high millimolar-range concentrations of ATP to become activated. ATP binding trigers the rapid opening of the channel and allows Na(+) and Ca(2+) influx and K(+) efflux. Has also the ability to form a large pore in the cell membrane, allowing the passage of large cationic molecules. In microglia, may mediate NADPH transport across the plasma membrane.

1. Chessell, IP. et al. (1998) FEBS letters 439, 26-30. PMID: 9849870

2. Robinson, LE. et al. (2014) The Journal of biological chemistry 289, 31983-31994. PMID: 25281740

3. Karmakar, M. et al. (2016) Nature communications 7, 10555. PMID: 26877061

4. Di, A. et al. (2018) Immunity 49, 56-65.e4. PMID: 29958799

5. Yang, D. et al. (2015) Immunity 43, 923-32. PMID: 26572062

Note

For research use only

Images

References

Datasheet

Anti-P2RX7 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-P2RX7 Polyclonal Antibody (MV713014)

Overview

Images

References

Datasheet

SDS

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