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Anti-PAK2 Polyclonal Antibody (HC597014)

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Overview
Catalog No.HC597014
Description
Anti-PAK2 Polyclonal Antibody (HC597014) is a rabbit polyclonal antibody detecting PAK2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human PAK2 (Glu177-Ala419).
Target S6/H4 kinase, p21-activated kinase 2, p58, PAK-2, PAK2, C-t-PAK2, PAK65, p34, Gamma-PAK, Serine/threonine-protein kinase PAK 2, p27
Purification Purified by antigen affinity column.
Accession Q13177
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Serine/threonine-protein kinase PAK 2 (PAK2) is a ~58 kDa protein. Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.

1. Jakobi, R. et al. (2003) The Journal of biological chemistry 278, 38675-85. PMID: 12853446
2. Vilas, GL. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 6542-7. PMID: 16617111
3. Mitsushima, M. et al. (2009) Molecular and cellular biology 29, 2816-27. PMID: 19273597
4. Hsu, RM. et al. (2010) Molecular biology of the cell 21, 287-301. PMID: 19923322
5. Antonarakis, SE. et al. (2021) Human molecular genetics 31, 1-9. PMID: 33693784
6. Martin, GA. et al. (1995) The EMBO journal 14, 1970-8. PMID: 7744004
7. Rudel, T. et al. (1997) Science (New York, N.Y.) 276, 1571-4. PMID: 9171063
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-PAK2 Polyclonal Antibody

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