Anti-pan-MAGUK Recombinant Antibody (K28/86) (HX973033)

Name: Anti-pan-MAGUK Recombinant Antibody (K28/86)
Brand: abinScience
SKU: HX973033
Price: 196 USD
Availability: InStock

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1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HX973033

Species reactivity

Drosophila melanogaster (Fruit fly)

Applications

IHC, IP, WB

Host species

Mouse

Isotype

IgG1, kappa

Clone ID

K28/86

Clonality

Monoclonal

Target

PSD-95, PSD95, Disks large homolog 4, Synapse-associated protein 90, DLG4, Postsynaptic density protein 95, SAP-90, SAP90

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P78352

RRID

Anti-pan-MAGUK Antibody (K28/86) (abinScience Cat# HX973033, RRID:AB_3727042)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Disks large homolog 4 (Membrane-associated guanylate kinases (MAGUK)) is a ~80 kDa protein. Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly.

1. Brigidi, GS. et al. (2015) Nature communications 6, 8200. PMID: 26334723

Note

For research use only.

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