Anti-PAX5 Polyclonal Antibody (HX975014)

Name: Anti-PAX5 Polyclonal Antibody
Brand: abinScience
SKU: HX975014
Price: 168 USD
Availability: InStock

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Overview
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SDS

Overview

Catalog No.

HX975014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PAX5 (Met1-His391).

Target

B-cell-specific transcription factor, Paired box protein Pax-5, BSAP, PAX5

Purification

Purified by antigen affinity column.

Accession

Q02548

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Paired box protein Pax-5 (PAX5) is a ~42 kDa protein. Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire.

1. Eberhard, D. et al. (2000) The EMBO journal 19, 2292-303. PMID: 10811620

2. Inagaki, Y. et al. (2016) Biochemical and biophysical research communications 475, 176-81. PMID: 27181361

3. Hill, L. et al. (2020) Nature 584, 142-147. PMID: 32612238

Note

For research use only.

Images

References

Datasheet

Anti-PAX5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

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Anti-PAX5 Polyclonal Antibody (HX975014)

Overview

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References

Datasheet

SDS

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