Anti-PBLD Polyclonal Antibody (HA616014)

Name: Anti-PBLD Polyclonal Antibody
Brand: abinScience
SKU: HA616014
Price: 96 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HA616014

Description

Anti-PBLD Polyclonal Antibody (HA616014) is a rabbit polyclonal antibody detecting Phenazine biosynthesis-like domain-containing protein; 5.1.-.-; MAWD-binding protein; MAWDBP; Unknown protein 32 from 2D-page of liver tissue; PBLD; MAWBP in ELISA, IHC, WB. Suitable for Human and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant human PBLD (Met1-Ala288).

Target

Phenazine biosynthesis-like domain-containing protein; 5.1.-.-; MAWD-binding protein; MAWDBP; Unknown protein 32 from 2D-page of liver tissue; PBLD; MAWBP

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P30039, Q2HJF4

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Phenazine biosynthesis-like domain-containing protein (PBLD) is a ~31 kDa protein. Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication by enhancing type I interferon (IFN-I) response. PBLD enhances IFN-I signaling via multiple pathways. Promotes IRF3-mediated IFN-I production and apoptosis, thereby inhibiting viral replication. Upregulates IFN-I response by activating the NF-kappaB signaling pathway, potentially through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection. Additionally, promotes the p53-USP4-MAVS signaling axis by stabilizing MAVS through USP4-mediated deubiquitination, thereby enhancing the IFN-I response against RNA virus infection.

1. Zhu, H. et al. (2024) Cell death & disease 15, 727. PMID: 39362857

2. Chu, F. et al. (2024) Proceedings of the National Academy of Sciences of the United States of America 121, e2401174121. PMID: 39589880

3. Hou, P. et al. (2025) Nature communications 16, 496. PMID: 39779683

4. Li, DM. et al. (2013) World journal of gastroenterology 19, 2781-92. PMID: 23687415

Note

For research use only

Images

Western blot

Western blot analysis was performed using anti-PBLD polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse liver lysate

References

Datasheet

Anti-PBLD Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-PBLD Polyclonal Antibody (HA616014)

Overview

Images

References

Datasheet

SDS