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Anti-PDE1C Polyclonal Antibody (HC446014)

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Overview
Catalog No.HC446014
Description
Anti-PDE1C Polyclonal Antibody (HC446014) is a rabbit polyclonal antibody detecting PDE1C in ELISA, IHC, WB. Suitable for Mouse, Human, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human PDE1C (Arg284-Asp630).
Target PDE1C, Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1C, Cam-PDE 1C, 3', 5'-cyclic-GMP phosphodiesterase, 3', 5'-cyclic-AMP phosphodiesterase, Hcam3
Purification Purified by antigen affinity column.
Accession Q14123
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (PDE1C) is a ~80 kDa protein. Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable).

1. Wang, L. et al. (2018) Human genetics 137, 437-446. PMID: 29860631
2. Loughney, K. et al. (1996) The Journal of biological chemistry 271, 796-806. PMID: 8557689
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-PDE1C Polyclonal Antibody

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