Anti-Phospho-KCNB1 (pS563) Recombinant Antibody (L83/11R) (RC581013)

Name: Anti-Phospho-KCNB1 (pS563) Recombinant Antibody (L83/11R)
Brand: abinScience
SKU: RC581013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

RC581013

Species reactivity

Rat

Applications

IHC, IP, WB

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

L83/11R

Clonality

Monoclonal

Target

h-DRK1, Delayed rectifier potassium channel 1, Potassium voltage-gated channel subfamily B member 1, KCNB1, Voltage-gated potassium channel subunit Kv2.1, DRK1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P15387

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Potassium voltage-gated channel subfamily B member 1 (p-KCNB1) is a ~95 kDa protein. Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Also plays a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane.

1. Murakoshi, H. et al. (1999) The Journal of neuroscience : the official journal of the Society for Neuroscience 19, 1728-35. PMID: 10024359

2. Du, J. et al. (2000) The Journal of physiology 522 Pt 1, 19-31. PMID: 10618149

3. Malin, SA. et al. (2002) The Journal of neuroscience : the official journal of the Society for Neuroscience 22, 10094-105. PMID: 12451110

4. Guan, D. et al. (2007) The Journal of physiology 581, 941-60. PMID: 17379638

5. Mohapatra, DP. et al. (2009) Channels (Austin, Tex.) 3, 46-56. PMID: 19276663

6. Guan, D. et al. (2013) The Journal of physiology 591, 4807-25. PMID: 23878373

7. Feinshreiber, L. et al. (2010) Journal of cell science 123, 1940-7. PMID: 20484665

8. Ju, M. et al. (2003) The Journal of biological chemistry 278, 12769-78. PMID: 12560340

9. Taglialatela, M. et al. (1991) Molecular pharmacology 40, 299-307. PMID: 1875913

10. VanDongen, AM. et al. (1990) Neuron 5, 433-43. PMID: 2206531

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Phospho-KCNB1 (pS563) Antibody (L83/11R)

References

Datasheet

Anti-Phospho-KCNB1 (pS563) Recombinant Antibody (L83/11R).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Phospho-KCNB1 (pS563) Recombinant Antibody (L83/11R) (RC581013)

Overview

Images

References

Datasheet

SDS

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