Anti-PIDD1 Polyclonal Antibody (HV498014)

Name: Anti-PIDD1 Polyclonal Antibody
Brand: abinScience
SKU: HV498014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HV498014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PIDD1 (Phe694-Arg885).

Target

Leucine-rich repeat and death domain-containing protein, PIDD1, p53-induced death domain-containing protein 1, PIDD, LRDD

Purification

Purified by antigen affinity column.

Accession

Q9HB75

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

p53-induced death domain-containing protein 1 (PIDD1) is a ~99 kDa protein. Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B.

1. Lin, Y. et al. (2000) Nature genetics 26, 122-7. PMID: 10973264

2. Tinel, A. et al. (2004) Science (New York, N.Y.) 304, 843-6. PMID: 15073321

3. Janssens, S. et al. (2005) Cell 123, 1079-92. PMID: 16360037

4. Tinel, A. et al. (2007) The EMBO journal 26, 197-208. PMID: 17159900

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-PIDD1 polyclonal antibody at 1ug/mL on recombinant PIDD1 (Catalog No. HV498012).

References

Datasheet

Anti-PIDD1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-PIDD1 Polyclonal Antibody (HV498014)

Overview

Images

References

Datasheet

SDS

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