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Anti-PLA2G2A Polyclonal Antibody (HB944014)

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Overview
Catalog No.HB944014
Description
Anti-PLA2G2A Polyclonal Antibody (HB944014) is a rabbit polyclonal antibody detecting PLA2G2A in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human PLA2G2A (Asn21-Cys144).
Target Phosphatidylcholine 2-acylhydrolase 2A, NPS-PLA2, RASF-A, Non-pancreatic secretory phospholipase A2, Group IIA phospholipase A2, GIIC sPLA2, PLA2L, PLA2G2A, PLA2B, Phospholipase A2, membrane associated
Purification Purified by antigen affinity column.
Accession P14555
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Phospholipase A2, membrane associated (PLA2G2A) is a ~16 kDa protein. Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines. Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane. Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes.

1. Ishizaki, J. et al. (1999) The Journal of biological chemistry 274, 24973-9. PMID: 10455175
2. Suzuki, N. et al. (2000) The Journal of biological chemistry 275, 5785-93. PMID: 10681567
3. Kramer, RM. et al. (1989) The Journal of biological chemistry 264, 5768-75. PMID: 2925633
4. Laine, VJ. et al. (1999) Journal of immunology (Baltimore, Md. : 1950) 162, 7402-8. PMID: 10358193
5. Koduri, RS. et al. (2002) The Journal of biological chemistry 277, 5849-57. PMID: 11694541
6. Boudreau, LH. et al. (2014) Blood 124, 2173-83. PMID: 25082876
7. Sun, YX. et al. (2004) The Biochemical journal 380, 749-56. PMID: 14998370
8. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536
9. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-PLA2G2A Polyclonal Antibody

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