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Anti-PMS2 Polyclonal Antibody (HA596014)

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Overview
Catalog No.HA596014
Description
Anti-PMS2 Polyclonal Antibody (HA596014) is a rabbit polyclonal antibody detecting Mismatch repair endonuclease PMS2; 3.1.-.-; DNA mismatch repair protein PMS2; PMS1 protein homolog 2; PMS2; PMSL2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant human PMS2 (Asp19-Asn371).
Target Mismatch repair endonuclease PMS2; 3.1.-.-; DNA mismatch repair protein PMS2; PMS1 protein homolog 2; PMS2; PMSL2
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P54278, Q13401, Q13670, A4D2B8, P54279, A8MQ11, O95744
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Mismatch repair endonuclease PMS2 is a ~95 kDa protein. Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch.

1. D'Arcy, BM. et al. (2019) Human mutation 40, 458-471. PMID: 30653781
2. D'Arcy, BM. et al. (2022) Molecular genetics & genomic medicine 10, e1908. PMID: 35189042
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-PMS2 Polyclonal Antibody

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