Anti-PQBP1 Polyclonal Antibody (HF653014)

Name: Anti-PQBP1 Polyclonal Antibody
Brand: abinScience
SKU: HF653014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HF653014

Description

Anti-PQBP1 Polyclonal Antibody (HF653014) is a rabbit polyclonal antibody detecting PQBP1 in ELISA, IHC, WB. Suitable for Bovine, Human, Mouse, Pongo pygmaeus, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PQBP1 (Met1-Asp265).

Target

NPW38, PQBP1, Polyglutamine tract-binding protein 1, PQBP-1, Npw38, 38 kDa nuclear protein containing a WW domain, Polyglutamine-binding protein 1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O60828

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Polyglutamine-binding protein 1 (PQBP1) is a ~30 kDa protein. Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development. Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death.

1. Komuro, A. et al. (1999) Nucleic acids research 27, 1957-65. PMID: 10198427

2. Waragai, M. et al. (1999) Human molecular genetics 8, 977-87. PMID: 10332029

3. Okazawa, H. et al. (2002) Neuron 34, 701-13. PMID: 12062018

4. Tapia, VE. et al. (2010) The Journal of biological chemistry 285, 19391-401. PMID: 20410308

5. Wang, Q. et al. (2013) Genes & development 27, 615-26. PMID: 23512658

Note

For research use only.

Images

References

Datasheet

Anti-PQBP1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-PQBP1 Polyclonal Antibody (HF653014)

Overview

Images

References

Datasheet

SDS

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