Anti-PSAT1 Polyclonal Antibody (HV252014)

Name: Anti-PSAT1 Polyclonal Antibody
Brand: abinScience
SKU: HV252014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HV252014

Description

Anti-PSAT1 Polyclonal Antibody (HV252014) is a rabbit polyclonal antibody detecting PSAT1 in ELISA, IHC, WB. Suitable for Human and Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PSAT1 (Met1-Gly312).

Target

Phosphohydroxythreonine aminotransferase, PSAT, PSAT1, PSA, Phosphoserine aminotransferase

Purification

Purified by antigen affinity column.

Accession

Q9Y617

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Phosphoserine aminotransferase (PSAT1) is a ~40 kDa protein. Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. Acts as an inhibitor of ferroptosis in response to interferon-gamma (IFNG) by promoting GPX4 stability: following phosphorylation by CAMK2A, PSAT1 interacts with GPX4 and provides 2-oxoglutarate to EGLN3, leading to GPX4 hydroxylation and stability.

1. Marchesani, F. et al. (2023) Protein science : a publication of the Protein Society 32, e4609. PMID: 36851825

2. Marchesani, F. et al. (2023) Biomolecules 13. PMID: 37627284

3. Zheng, P. et al. (2025) Nature chemical biology 21, 1420-1432. PMID: 40281343

Note

For research use only.

Images

References

Datasheet

Anti-PSAT1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-PSAT1 Polyclonal Antibody (HV252014)

Overview

Images

References

Datasheet

SDS

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