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Anti-Pseudomonas aeruginosa impA Polyclonal Antibody (JN076034)

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Overview
Catalog No.JN076034
Description
Anti-Pseudomonas aeruginosa impA Polyclonal Antibody (JN076034) is a rabbit polyclonal antibody detecting IMPa. Suitable for Pseudomonas aeruginosa.
Species reactivityPseudomonas aeruginosa
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Pseudomonas aeruginosa impA (Ala42-Pro923).
Target EC:3.4.24.-, IMPa, Immunomodulating metalloprotease, impA
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9I5W4
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Immunomodulating metalloprotease (impA) is a ~100 kDa protein. Protease that degrades several proteins of the host immune system. Cleaves P-selectin glycoprotein ligand-1 (PSGL-1), leading to its functional inhibition; PSGL-1 is a leukocyte cell-surface receptor essential for leukocyte recruitment to the site of infection. Next to PSGL-1, targets host CD43 and CD44 that are also involved in leukocyte homing. Thus, prevents neutrophil extravasation and thereby protects P.aeruginosa from neutrophil attack. Is also able to inhibit the decay accelerating factor (CD55), but not the cell-surface receptors CD46 and CD31.

Note For research use only
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