Anti-RAB11A Polyclonal Antibody (HX202014)

Name: Anti-RAB11A Polyclonal Antibody
Brand: abinScience
SKU: HX202014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HX202014

Description

Anti-RAB11A Polyclonal Antibody (HX202014) is a rabbit polyclonal antibody detecting RAB11A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human RAB11A (Met1-Glu162).

Target

Rab-11, RAB11A, RAB11, YL8, Ras-related protein Rab-11A

Purification

Purified by antigen affinity column.

Accession

P62491

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ras-related protein Rab-11A (RAB11A) is a ~24 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB11A regulates endocytic recycling. Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC). Acts as a major regulator of membrane delivery during cytokinesis.

1. Wilson, GM. et al. (2005) Molecular biology of the cell 16, 849-60. PMID: 15601896

2. Lock, JG. et al. (2005) Molecular biology of the cell 16, 1744-55. PMID: 15689490

3. Swiatecka-Urban, A. et al. (2007) The Journal of biological chemistry 282, 23725-36. PMID: 17462998

4. Chu, BB. et al. (2009) The Journal of biological chemistry 284, 22481-22490. PMID: 19542231

5. Horgan, CP. et al. (2010) Journal of cell science 123, 181-91. PMID: 20026645

6. Bryant, DM. et al. (2010) Nature cell biology 12, 1035-45. PMID: 20890297

7. Roland, JT. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2789-94. PMID: 21282656

8. Lall, P. et al. (2015) The Journal of biological chemistry 290, 18817-32. PMID: 26032412

9. Wang, J. et al. (2015) Journal of cell science 128, 1375-85. PMID: 25673879

10. Walia, V. et al. (2019) Developmental cell 50, 229-246.e7. PMID: 31204173

Note

For research use only.

Images

References

Datasheet

Anti-RAB11A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-RAB11A Polyclonal Antibody (HX202014)

Overview

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Datasheet

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