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Anti-Rabbit IL-1 beta/IL-1F2 Polyclonal Antibody (TF943014)

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Overview
Catalog No.TF943014
Description
Anti-Rabbit IL1B/IL1F2 Polyclonal Antibody (TF943014) is a rabbit polyclonal antibody detecting IL1B. Suitable for Rabbit.
Species reactivityRabbit
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Rabbit IL1B/IL1F2 (Ala117-Ser268).
Target IL-1 beta, IL1B, Interleukin-1 beta, Lymphocyte proliferation-potentiating factor
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P14628
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Interleukin-1 beta (IL1B/IL1F2) is a ~30 kDa protein. Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. IL1B is the therapeutic target of canakinumab (Ilaris).

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Anti-Rabbit IL-1 beta/IL-1F2 Polyclonal Antibody

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