

| Catalog No. | HW462014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-RCVRN Polyclonal Antibody (HW462014) is a rabbit polyclonal antibody detecting RCVRN in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, and Bovine.
Highlights
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| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human RCVRN (Gly2-Ala200). | ||||||||
| Target | RCVRN, Recoverin, RCV1, Cancer-associated retinopathy protein, Protein CAR | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P35243 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Recoverin (RCVRN) is a ~23 kDa protein. Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells. Modulates light sensitivity of cone photoreceptor in dark and dim conditions. In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin. Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells. Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light. | ||||||||
| Note | For research use only. |
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