

| Catalog No. | HX238014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-RELB Polyclonal Antibody (HX238014) is a rabbit polyclonal antibody detecting RELB in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Species reactivity | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human RELB (Asp248-Asp492). | ||||||||
| Target | RELB, Transcription factor RelB, I-Rel | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q01201 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Transcription factor RelB is a ~62 kDa protein. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. 1. Sharfe, N. et al. (2015) Journal of autoimmunity 65, 90-100. PMID: 26385063 | ||||||||
| Note | For research use only. |
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