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Anti-REXO2 Polyclonal Antibody (HV708014)

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Overview
Catalog No.HV708014
Description
Anti-REXO2 Polyclonal Antibody (HV708014) is a rabbit polyclonal antibody detecting REXO2 in ELISA, IHC, WB. Suitable for Mouse, Bovine, Human, and Rat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human REXO2 (Gln41-Asn213).
Target Small fragment nuclease, SMFN, REXO2, Oligoribonuclease, mitochondrial, RNA exonuclease 2 homolog, SFN
Purification Purified by antigen affinity column.
Accession Q9Y3B8
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Oligoribonuclease, mitochondrial (REXO2) is a ~26 kDa protein. 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development.

1. Bruni, F. et al. (2013) PloS one 8, e64670. PMID: 23741365
2. Chu, LY. et al. (2019) RNA (New York, N.Y.) 25, 737-746. PMID: 30926754
3. Nicholls, TJ. et al. (2019) Molecular cell 76, 784-796.e6. PMID: 31588022
4. Szewczyk, M. et al. (2020) Nucleic acids research 48, 5572-5590. PMID: 32365187
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-REXO2 Polyclonal Antibody

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