

| Catalog No. | HB570014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-RNF113A Polyclonal Antibody (HB570014) is a rabbit polyclonal antibody detecting E3 ubiquitin-protein ligase RNF113A; 2.3.2.27; Cwc24 homolog; RING finger protein 113A; Zinc finger protein 183; RNF113A; RNF113; ZNF183 in ELISA, IHC, WB. Suitable for Human and Bovine.
Highlights
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| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant human RNF113A (Ile201-Thr343). | ||||||||
| Target | E3 ubiquitin-protein ligase RNF113A; 2.3.2.27; Cwc24 homolog; RING finger protein 113A; Zinc finger protein 183; RNF113A; RNF113; ZNF183 | ||||||||
| Endotoxin level | Please contact with the lab for this information. | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | O15541, Q67ER4 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | E3 ubiquitin-protein ligase RNF113A is a ~38 kDa protein. Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. 1. Zhang, X. et al. (2018) Cell research 28, 307-322. PMID: 29360106 2. Haselbach, D. et al. (2018) Cell 172, 454-464.e11. PMID: 29361316 3. Lear, T. et al. (2017) American journal of physiology. Cell physiology 313, C584-C592. PMID: 28978524 4. Brickner, JR. et al. (2017) Nature 551, 389-393. PMID: 29144457 | ||||||||
| Note | For research use only |
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