

| Catalog No. | HW639014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-RYK Polyclonal Antibody (HW639014) is a rabbit polyclonal antibody detecting RYK in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| Species reactivity | Human, Mouse | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human RYK (Leu308-Pro568). | ||||||||
| Target | Tyrosine-protein kinase RYK, RYK, JTK5A | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P34925 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Tyrosine-protein kinase RYK is a ~67 kDa protein. May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. | ||||||||
| Note | For research use only. |
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